NSC 745887 ( NSC745887 )

产品货号. M14957 CAS No. 54490-26-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

NSC 745887
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.
产品描述

NSC 745887 is a small molecule that effectively inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage, shows anticancer effects against human GBM cells via suppressing DcR3-associated signaling pathways; increases the sub-G1 population in dose- and time-dependent manners in GBM cells, increases expression of γH2AX and causes DNA fragmentation leading to DNA damage; suppresses the [18F]-FDG-specific uptake value in brain tumors.
同义词

NSC745887
通路

Apoptosis
靶点

Apoptosis
受体

Apoptosis
研究领域

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适应症

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1. Fann LY, et al. Oncotarget. 2017 Dec 27;9(15):11922-11937.

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